Stanford O'Brien Urology Center
Stanford O'Brien Urology Research Center
Creating a detailed map of prostate enlargement to learn what causes benign prostatic hyperplasia (BPH) and bothersome urinary symptoms in older men.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-11142394 on NIH RePORTER |
What this research studies
They are building an integrated atlas of BPH by combining prostate tissue, clinical data, molecular testing, and high-resolution imaging to study cells, genes, and the surrounding tissue environment. The team will collect samples and information from men with BPH, perform molecular and cellular profiling, and generate 3-D models and images to link microscopic changes to organ-level features. Dedicated cores will standardize biospecimen handling and bioimaging so findings can be compared across patients. The center will share data and tools to help other researchers develop new ways to treat or prevent prostate enlargement.
Who could benefit from this research
Good fit: Men with benign prostatic hyperplasia or bothersome lower urinary tract symptoms, particularly those undergoing prostate procedures or willing to donate tissue, urine, or imaging data, are the ideal candidates.
Not a fit: People without BPH (including women and men with unrelated urologic conditions) are unlikely to directly benefit from this project.
Why it matters
Potential benefit: If successful, this could reveal new targets or strategies to prevent or treat BPH and reduce urinary symptoms in affected men.
How similar studies have performed: Molecular and tissue atlases in other conditions (for example, cancer) have led to useful discoveries, but a comprehensive human BPH atlas is relatively new and less tested.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Brooks, James D. — Stanford University
- Study coordinator: Brooks, James D.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.