Standardizing Alzheimer's diagnoses and symptom data across U.S. and African sites
Core C: Adjudication and Phenotype Harmonization
This project creates consistent, high-quality Alzheimer's diagnoses and symptom records from thousands of U.S. and African participants so researchers can study genetic differences across diverse groups.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project ID | NIH-11126003 on NIH RePORTER |
What this research studies
From the patient's perspective, the team will gather clinical records and symptom information from about 13,000 people (roughly 8,000 in the U.S. and 5,000 in African cohorts). They will create common data guides and adjudicate diagnoses so that different sites' records speak the same language. The core will harmonize multi-domain clinical measures and deliver cleaned diagnoses and datasets to other project teams and public repositories. This makes it easier for researchers everywhere to use the same, analysis-ready information when searching for Alzheimer's-related genes, especially in groups that have been underrepresented.
Who could benefit from this research
Good fit: People with Alzheimer’s disease, mild cognitive impairment, or older adults who served as controls at participating U.S. or African research sites are the kinds of participants represented in this project.
Not a fit: This project does not provide clinical care or experimental treatments, so individuals seeking immediate medical therapy are unlikely to gain direct benefit.
Why it matters
Potential benefit: If successful, the work could make genetic research more inclusive and speed discoveries that lead to better, more equitable Alzheimer's tests and treatments.
How similar studies have performed: Prior data harmonization and adjudication efforts have enabled important genetic discoveries, and this project applies those methods at larger scale with a focus on underrepresented African cohorts.
Where this research is happening
Coral Gables, United States
- University of Miami School of Medicine — Coral Gables, United States (Active)
Researchers
- Principal investigator: Cuccaro, Michael L — University of Miami School of Medicine
- Study coordinator: Cuccaro, Michael L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.