Standardized lab tests for detecting early lung cancer and predicting recurrence
Biomarker Reference Lab
This project is creating blood and airway tests to spot early-stage lung cancer and help predict if it will come back after surgery.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11325353 on NIH RePORTER |
What this research studies
This project is developing lab-grade blood and lower airway tests to find signs of early-stage lung cancer and predict post-surgical recurrence. It uses matched plasma, buffy coat, and airway samples from patients like you to confirm the discoveries from earlier work. Researchers will build targeted microbial genomic panels (NGS), metabolite panels using LC-MS, and host-gene panels using NanoString to measure the most promising markers. The tests will be standardized and analytically validated to CLIA quality so they could eventually be used in clinical care.
Who could benefit from this research
Good fit: People with suspected or newly diagnosed early-stage non-small cell lung cancer, and patients who have had surgery for early-stage NSCLC, are the ideal candidates for this work.
Not a fit: Patients with advanced or metastatic lung cancer, non-lung cancers, or unrelated medical conditions are unlikely to benefit directly from these specific assays.
Why it matters
Potential benefit: If successful, these validated tests could enable earlier detection of lung cancer and better prediction of recurrence, guiding treatment and follow-up decisions.
How similar studies have performed: Previous studies have shown promising blood- and genomic-based biomarkers for lung cancer, but few have been standardized and CLIA-validated for clinical use so far.
Where this research is happening
New York, United States
- New York University School of Medicine — New York, United States (Active)
Researchers
- Principal investigator: Segal, Leopoldo Nicolas — New York University School of Medicine
- Study coordinator: Segal, Leopoldo Nicolas
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.