Stable, potent peptide drug conjugate for treating triple-negative breast cancer

Who could benefit from this research

What this research studies

This project aims to improve delivery of a toxic payload to cancer cells that express the LHRH receptor, using a stable linker to enhance efficacy and safety. Researchers will test novel drug conjugates in preclinical models and in early development studies to optimize stability, potency, and tumor targeting. If successful, this work could lead to future clinical trials for patients with TNBC who express LHRH receptors. The collaboration involves ONCOTHERAPY SOLUTIONS, LLC, and focuses on translating lab findings into a therapy that selectively attacks cancer cells while minimizing harm to healthy tissue.

Why it matters

Where this research is happening

• Oncotherapy Solutions, LLC
  Seattle, United States Active

Researchers

• Principal investigator: Lamharzi, Najib — Oncotherapy Solutions, LLC
• Study coordinator: Lamharzi, Najib

Related research

Other NIH-funded projects on the same topics.

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  NIH research Tuskegee University · Tuskegee Institute, United States · NIH-11621786

• Co-Targeting IL-6 and CDK4/6 to Prevent TNBC in Women Veterans

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• Linking heavy metal exposure to a tougher breast cancer type (TNBC)

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  NIH research University of Louisville · Louisville, United States · NIH-11567535

• Dormancy in Triple-Negative Breast Cancer: How Liver and Skin Metastases Go Quiet or Reactivate

  Researchers will study how dormant cancer cells in liver and skin metastases of triple-negative breast cancer become quiescent or wake up, using organ-on-chip models and single-cell analysis to map chromatin states.

  NIH research Massachusetts Institute of Technology · Cambridge, United States · NIH-11531542

• Rac-enhanced CAR-Macrophages against TNBC

  A new cell therapy approach uses engineered macrophages with a CAR and Rac2 activation to target and kill triple-negative breast cancer cells expressing CSPG4.

  NIH research University of Louisville · Louisville, United States · NIH-11520503

• A new peptide therapy to help treat metastatic triple-negative breast cancer

  A new peptide therapy called PEG-FUD is being tested to help treat metastatic triple-negative breast cancer by normalizing the tumor environment to improve treatment delivery.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-11453153

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.