Spread and evolution of drug-resistant tuberculosis in Moldova
Evolution, transmission, and control of drug-resistant tuberculosis
This project looks at how two types of drug-resistant tuberculosis spread and change over time in people in Moldova.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11139512 on NIH RePORTER |
What this research studies
If you have active tuberculosis in Moldova, researchers will use bacteria samples taken before treatment to learn how the strains spread and evolved. They will sequence the bacterial DNA from patients across the country and compare two main drug-resistant lineages called Beijing and Ural. The team will map where and how fast each lineage has grown since 2010 and look for genetic changes that help them survive drugs and spread. Findings will be compared with patient and location data to guide better public health responses.
Who could benefit from this research
Good fit: Ideal participants are people in Moldova with culture-positive tuberculosis who can provide bacterial samples and linked clinical or location information.
Not a fit: People without active tuberculosis, those with only latent TB infection, or patients outside Moldova are unlikely to be direct participants or gain immediate benefit from this project.
Why it matters
Potential benefit: If successful, this work could help health officials target infection control and treatment strategies to reduce spread of multidrug-resistant TB in Moldova.
How similar studies have performed: Genome sequencing has been used successfully elsewhere to trace TB transmission and drug resistance, but applying it to Moldova's specific Beijing and Ural lineages is a focused, novel effort.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Cohen, Theodore H — Yale University
- Study coordinator: Cohen, Theodore H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.