Spinal cord injury leads to liver problems and metabolic issues
Spinal cord injury causes liver pathology and metabolic dysfunction
This study is looking at how spinal cord injuries can lead to liver problems and affect overall health, especially focusing on a serious liver condition called NASH, to help find better ways to support people with spinal cord injuries.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project ID | NIH-11084562 on NIH RePORTER |
What this research studies
This research investigates how spinal cord injuries (SCI) can cause liver damage and metabolic dysfunction, which significantly affect the health and lifespan of individuals with SCI. The study focuses on understanding the mechanisms behind non-alcoholic steatohepatitis (NASH), a severe liver condition that is prevalent in SCI patients. By examining the role of increased sympathetic nervous system activity on liver function, the researchers aim to identify pathways that contribute to inflammation and fat accumulation in the liver. The approach includes using advanced mouse models to explore these biological processes and their implications for overall health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced spinal cord injuries and are at risk for metabolic syndrome and liver disease.
Not a fit: Patients without spinal cord injuries or those who do not exhibit metabolic dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for liver and metabolic disorders in individuals with spinal cord injuries.
How similar studies have performed: Previous research has shown that understanding the metabolic consequences of spinal cord injuries can lead to significant advancements in patient care, indicating that this approach has potential for success.
Where this research is happening
Columbus, UNITED STATES
- Ohio State University — Columbus, United States (Active)
Researchers
- Principal investigator: Mctigue, Dana M — Ohio State University
- Study coordinator: Mctigue, Dana M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.