Special MRI scans to better predict breast cancer response to chemotherapy
Breast Cancer Intravoxel-incoherent-motion MRI Multisite (BRIMM) Study - Resubmission - 1
['FUNDING_OTHER'] · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · NIH-11182618
This project tests whether a special MRI method (IVIM) can spot early signs that breast cancer will or won't respond to chemotherapy in people receiving pre-surgery treatment.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NEW YORK UNIVERSITY SCHOOL OF MEDICINE (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11182618 on ClinicalTrials.gov |
What this research studies
If you join, researchers will gather past IVIM MRI scans from five hospitals to see how measurements differ across scanner brands and software. Then they will follow patients at two sites who are getting chemotherapy before surgery and take IVIM MRI scans before and during treatment. The team will compare results within each site and across the combined group to find MRI markers that change when tumors respond. The goal is to identify MRI measurements that are reliable across hospitals so doctors could use them more broadly.
Who could benefit from this research
Good fit: People with breast cancer who are starting or receiving neoadjuvant (pre-surgery) chemotherapy and can have MRI scans at a participating center are ideal candidates.
Not a fit: People not receiving neoadjuvant chemotherapy or those who cannot undergo MRI (for example due to incompatible implants or severe claustrophobia) are unlikely to benefit from this project.
Why it matters
Potential benefit: If successful, this could help doctors know earlier whether chemotherapy is working and tailor treatment sooner.
How similar studies have performed: Single-site IVIM MRI studies in breast and other cancers have shown promising results, but multisite validation of these markers is limited.
Where this research is happening
NEW YORK, UNITED STATES
- NEW YORK UNIVERSITY SCHOOL OF MEDICINE — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SIGMUND, ERIC EDWARD — NEW YORK UNIVERSITY SCHOOL OF MEDICINE
- Study coordinator: SIGMUND, ERIC EDWARD
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.