Spatiotemporal Control of G-protein Signaling in Human Health and Disease
Official title: Spatiotemporal Control of G-protein Signaling
Funded at University of Maine Orono · NIH-11320020 · Data updated 2026-11-12
A study from the University of Maine explores how cells control signaling proteins to better understand diseases like cancer and heart disorders.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Maine Orono NIH-funded |
| Lab location | 1 site (Orono, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2027 |
| Funding year | 2026 |
| Award (this year) | $62,446 |
| NIH project number | 3R15GM155864-01S1 |
| Project ID | NIH-11320020 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are patients or patient samples affected by cancers or cardiac disorders where GPCR signaling plays a role, or individuals interested in participating in future translational studies.
✕Less likely to help
This basic science work uses yeast models and may not directly involve patients or immediate clinical applications.
What this research studies
Researchers will study how G-protein signaling is turned on and off inside cells, focusing on Regulators of G-protein Signaling (RGS) proteins. They will use live cell imaging and biochemical tests in yeast models to uncover how RGS proteins interact with receptors and cell structures to shape responses over time. The project aims to reveal how these signaling dynamics influence processes like cell communication, growth, and disease progression. Findings could point to new ways to modulate signaling in cancer and cardiac conditions.
Why it matters
Potential benefit: Understanding these signaling dynamics could inform future therapies that fine-tune cellular communication in cancer and heart diseases.
How similar studies have gone: Previous work shows that signaling dynamics influence cell behavior, with potential for translational impact in humans, though this exact approach is novel.
Where this research is happening
-
University of Maine Orono
Orono, United States Active
Researchers
- Principal investigator: Kelley, Joshua Brian — University of Maine Orono
- Study coordinator: Kelley, Joshua Brian
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.