Spatially mapped single-cell DNA sequencing for HIV reservoir insights
Official title: Spatially Resolved Single-Cell DNA Sequencing: A General Spatial Genomics Platform with Application to HIV Reservoir Mapping
Funded at Vivid Bioinnovations, Pbc · NIH-11316768 · Data updated 2026-11-12
A new platform will map DNA, RNA, and proteins in tissue from HIV patients at high spatial resolution to better understand reservoirs.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vivid Bioinnovations, Pbc NIH-funded |
| Lab location | 1 site (San Francisco, UNITED STATES) |
| Project start | September 1, 2026 |
| Project end | August 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $299,991 |
| NIH project number | 1R44AI197850-01 |
| Project ID | NIH-11316768 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates would be individuals with HIV infection where tissue samples (e.g., from biopsies) could be studied for reservoir mapping.
✕Less likely to help
This grant does not involve direct patient treatment or recruitment for a clinical trial.
What this research studies
This project aims to create a first commercially viable spatial genomics platform that can read DNA directly in tissue sections while preserving where cells sit. It will combine hydrogel-based barcoding, advanced microfluidics, and Bayesian algorithms to capture DNA, RNA, and protein from individual cells in place. The goal is to analyze very large tissue samples cost-effectively, enabling large-scale mapping of HIV reservoirs and related biology. The work builds on existing science and collaborations to push spatial genomics beyond current capabilities.
Why it matters
Potential benefit: If successful, the platform could enable precise mapping of HIV reservoirs in patient tissues, potentially guiding better-targeted therapies.
How similar studies have gone: Previous spatial genomics approaches have mapped transcripts and proteins, but this project extends the method to DNA sequencing in situ, representing a novel advancement.
Where this research is happening
-
Vivid Bioinnovations, Pbc
San Francisco, United States Active
Researchers
- Principal investigator: Hsieh, Satcher — Vivid Bioinnovations, Pbc
- Study coordinator: Hsieh, Satcher
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.