Sodium intake and mortality in a large adult cohort
Official title: The relationship between sodium intake and mortality: a case-cohort study in a population-based cohort of 148,000 adults with both 24-hour and spot urine samples
Funded at Stanford University · NIH-11601108 · Data updated 2026-11-12
A large study in adults looks at how different levels of salt intake relate to the risk of death, using both 24-hour and spot urine samples.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | August 23, 2023 |
| Project end | March 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $36,206 |
| NIH project number | 3R01HL166509-04S1 |
| Project ID | NIH-11601108 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are adults aged 21 and older who participate in long-term cohort follow-up and have available urine data.
✕Less likely to help
Participants not represented in the cohort or lacking relevant urine data may not benefit directly.
What this research studies
This project follows about 148,000 adults over time to see how their sodium intake relates to their risk of death. It compares traditional spot urine estimates with more accurate 24-hour urine measurements to understand if lower salt always means better outcomes. The study tests whether the previously observed J-shaped relationship is due to measurement methods. By analyzing a large, well-characterized cohort, researchers aim to clarify how sodium intake below average affects mortality. The findings could influence how public health guidelines address salt reduction at the population level.
Why it matters
Potential benefit: If successful, the study could inform more precise public health recommendations on salt intake to reduce mortality risk.
How similar studies have gone: Previous cohorts suggested a J-shaped sodium-mortality pattern, but results are debated due to measurement methods; this study aims to resolve that using 24-hour urine data in a large sample.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Geldsetzer, Pascal — Stanford University
- Study coordinator: Geldsetzer, Pascal
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.