Smarter sampling for long-term health studies
Outcome Dependent Sampling of Longitudinal Data: Design and Analysis
['FUNDING_R01'] · VANDERBILT UNIVERSITY MEDICAL CENTER · NIH-11327646
This project creates smarter ways to choose which patients’ records and stored samples to check so long-term studies can find important health signals more efficiently, including for people with HIV.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VANDERBILT UNIVERSITY MEDICAL CENTER (nih funded) |
| Locations | 1 site (NASHVILLE, UNITED STATES) |
| Trial ID | NIH-11327646 on ClinicalTrials.gov |
What this research studies
This work helps researchers pick the most informative people in long-term studies or clinical trials to test their blood samples or review their medical records, instead of testing everyone. It uses two-phase and outcome-dependent sampling to concentrate limited resources on participants more likely to provide useful information. The team also develops statistical methods to correct for the non-representative selection so results still apply to the whole study population. These methods are being extended to handle repeated (longitudinal) and ordered (ordinal) outcomes and can be applied to linked electronic health records and biobanks.
Who could benefit from this research
Good fit: Ideal candidates are people already enrolled in cohort studies or clinical trials that have linked electronic health records or stored biospecimens, for example people living with HIV who have banked samples or detailed records.
Not a fit: People not enrolled in such cohorts, without stored samples or linked records, or those expecting direct clinical care from this project are unlikely to receive direct benefit.
Why it matters
Potential benefit: If successful, this could let researchers get reliable answers faster and cheaper, speeding discovery of useful tests or treatments for conditions like HIV.
How similar studies have performed: Related outcome-dependent and two-phase sampling approaches have been used successfully in past studies, and this project builds on earlier funded work to extend those methods to longitudinal and ordinal data.
Where this research is happening
NASHVILLE, UNITED STATES
- VANDERBILT UNIVERSITY MEDICAL CENTER — NASHVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SCHILDCROUT, JONATHAN SCOTT — VANDERBILT UNIVERSITY MEDICAL CENTER
- Study coordinator: SCHILDCROUT, JONATHAN SCOTT
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome Virus