Sleep-wake rhythms and dementia in Latin American adults
Circadian Disturbance and Dementia in Latin America
['FUNDING_R01'] · MASSACHUSETTS GENERAL HOSPITAL · NIH-11402414
This project looks at whether changes in daily sleep and activity patterns are linked to Alzheimer's and related dementias in Latino adults aged 40 to 80.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MASSACHUSETTS GENERAL HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11402414 on ClinicalTrials.gov |
What this research studies
Researchers are using the ReDLat consortium database of over 3,000 Latino adults (with Alzheimer's disease, frontotemporal dementia, or no dementia) to study day-night activity and sleep patterns. They will combine wearable-device data, sleep and activity questionnaires, clinical tests, and genetic information such as APOE-ε4 to characterize circadian disturbance. The team will compare circadian measures across dementia types and control participants to see how rhythms relate to diagnosis and symptoms. Work is being done through partner clinics and existing participant visits across Latin America.
Who could benefit from this research
Good fit: Ideal candidates are Latino adults aged 40–80 with Alzheimer disease, frontotemporal lobar degeneration, or without dementia who are enrolled in or eligible for the ReDLat consortium at participating clinics.
Not a fit: People under 40, non-Latino individuals, or those with unrelated neurological conditions may not directly benefit from this project's findings.
Why it matters
Potential benefit: If successful, this work could identify sleep- and activity-related markers or targets that help prevent, delay, or better manage dementia in Latin American populations.
How similar studies have performed: Prior studies in the US and Europe have linked circadian disruption to cognitive decline, but applying this research specifically in Latin American populations is relatively new.
Where this research is happening
BOSTON, UNITED STATES
- MASSACHUSETTS GENERAL HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HU, KUN — MASSACHUSETTS GENERAL HOSPITAL
- Study coordinator: HU, KUN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia