Sleep and chromatin: how sleep shapes gene regulation across vertebrates
Official title: The role of sleep on chromatin and transcriptional regulation across vertebrate evolution.
Funded at Washington State University · NIH-11392959 · Data updated 2026-11-12
This NIH grant studies how sleep changes gene activity and chromatin in different animals, aiming to map conserved brain and body patterns across species.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington State University NIH-funded |
| Lab location | 1 site (Pullman, United States) |
| Project start | September 20, 2022 |
| Project end | August 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $382,500 |
| NIH project number | 5R35GM147020-05 |
| Project ID | NIH-11392959 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not applicable to patients directly, as the work uses animal models and multi-tissue analysis.
✕Less likely to help
No direct patient participation in this basic science project.
What this research studies
The project explores how sleep loss affects gene expression and chromatin at the single-cell level across vertebrates and tissues beyond the brain. Using advanced single-cell RNA and epigenomic techniques, the study compares responses to sleep loss in brain and non-brain tissues to identify conserved mechanisms. The findings could reveal how sleep helps stabilize learned behaviors by shaping the transcriptional landscape. Results may guide future research into sleep-related disorders and their impact on health.
Why it matters
Potential benefit: A better understanding of sleep’s role in regulating genes could inform therapies for sleep disorders and related health conditions.
How similar studies have gone: Previous work supports a link between sleep and gene regulation, with single-cell approaches offering deeper insight; this study extends that to cross-species comparisons.
Where this research is happening
-
Washington State University
Pullman, United States Active
Researchers
- Principal investigator: Peixoto, Lucia — Washington State University
- Study coordinator: Peixoto, Lucia
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.