Sleep across the lifespan and Alzheimer's risk
Lifecourse sleep, cognitive decline and risk of Alzheimer's disease: a pooled cohort study.
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · NIH-11306670
This project looks at how sleep patterns from young adulthood through older age relate to thinking skills and the chance of Alzheimer's in adults.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN FRANCISCO (nih funded) |
| Locations | 1 site (SAN FRANCISCO, UNITED STATES) |
| Trial ID | NIH-11306670 on ClinicalTrials.gov |
What this research studies
This project combines data from many long-term groups of adults to compare sleep patterns with memory and dementia over the life course. It uses both self-reported sleep information and objective measures (like wearable actigraphy), links those to repeated cognitive tests and dementia diagnoses, and includes genetic and biomarker data such as APOE. Researchers will examine when in life sleep problems are most strongly tied to later thinking decline and whether those links differ by race, sex, or other factors. The work pools existing cohort data rather than running a single new clinic trial, so it looks for patterns across diverse populations and long follow-up periods.
Who could benefit from this research
Good fit: Adults aged 21 and older who can share sleep histories, device-measured sleep data, cognitive test results, or biospecimens are the kinds of participants who could contribute.
Not a fit: People with advanced Alzheimer's disease or severe dementia are unlikely to receive direct benefit from this observational research.
Why it matters
Potential benefit: If successful, this work could identify when and how improving sleep might help prevent or delay memory loss and Alzheimer's disease.
How similar studies have performed: Previous studies have linked poor sleep with higher dementia risk, but timing, causality, and life-course patterns are still not fully resolved.
Where this research is happening
SAN FRANCISCO, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN FRANCISCO — SAN FRANCISCO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LENG, YUE — UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- Study coordinator: LENG, YUE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.