Skeletal Muscle's Influence on Lung Blood Vessels in Heart Failure
Role of Skeletal Muscle in Pulmonary Vascular Remodeling
This project explores how changes in skeletal muscle might contribute to a common type of high blood pressure in the lungs for people with heart failure.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project ID | NIH-11115796 on NIH RePORTER |
What this research studies
For people with heart failure and high blood pressure in their lungs (PH-HFpEF), there are currently no effective treatments. Our past work showed that a protein called sirtuin-3 (SIRT3) is lower in the skeletal muscle of these patients. We've now found a new way that muscle changes, specifically through SIRT3, might send signals that affect the blood vessels in the lungs. This project aims to understand how these muscle signals, including a protein called B2M which is higher in PH-HFpEF patients, lead to harmful changes in the lung's blood vessels.
Who could benefit from this research
Good fit: Patients living with pulmonary hypertension associated with heart failure with preserved ejection fraction (PH-HFpEF) would be the ideal candidates for future clinical applications of this research.
Not a fit: Patients without pulmonary hypertension or heart failure with preserved ejection fraction are unlikely to directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to treat pulmonary hypertension associated with heart failure, a condition for which effective therapies are currently lacking.
How similar studies have performed: This project builds upon previous findings from the research team regarding SIRT3 and has identified new signaling molecules, suggesting a novel approach based on prior successful foundational work.
Where this research is happening
Indianapolis, United States
- Indiana University Indianapolis — Indianapolis, United States (Active)
Researchers
- Principal investigator: Lai, Yen Chun Charly — Indiana University Indianapolis
- Study coordinator: Lai, Yen Chun Charly
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.