SIRPa differences and long-term kidney transplant loss
Innate Allorecognition in Clinical Organ Transplantation
This project looks at whether mismatches in a protein called SIRPa between donors and adult kidney transplant recipients cause immune cells to damage grafts over the long term.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-11383883 on NIH RePORTER |
What this research studies
If you take part, researchers will compare the SIRPa genes of donors and recipients in two large groups of adult kidney transplant pairs. They will use blood tests to study how recipient monocytes (a type of immune cell) behave and use detailed biopsy tissue imaging to see where immune cells are acting in the graft. The team will combine genetic matching information with cell profiling and spatial analysis of biopsies to link SIRPa mismatch with chronic graft injury and loss. This work uses existing clinical records, blood samples, and stored biopsy material from transplant patients.
Who could benefit from this research
Good fit: Ideal candidates are adult (21+) kidney transplant recipients and their donors, especially those with long-term follow-up and available biopsy and blood sample data.
Not a fit: People without a kidney transplant, pediatric transplant patients, or patients whose graft loss is driven by non-immune causes may not directly benefit from this work.
Why it matters
Potential benefit: If successful, the findings could help predict which donor–recipient pairs face higher risk and guide better matching or new treatments to prevent long-term kidney graft loss.
How similar studies have performed: Animal models and early human lab data support a role for SIRPa in monocyte responses, but using SIRPa mismatching to predict long-term clinical graft loss is a novel clinical application.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Lakkis, Fadi G. — Stanford University
- Study coordinator: Lakkis, Fadi G.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.