Sirolimus and everolimus dosing and effects in adults 65 and older
Pharmacokinetics (PK) and Pharmacodynamics (PD) Characterization of mTOR Inhibitors in Older Adults
This project measures how two mTOR drugs, sirolimus and everolimus, are processed and act in adults aged 65 and older to guide safer dosing and biomarkers.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-11173871 on NIH RePORTER |
What this research studies
You would be invited to join a team measuring how these drugs move through and affect the body in older adults without major illnesses. Participants will receive controlled doses and provide blood and other samples over time so researchers can measure drug levels and biological markers. The team will validate laboratory tests and use the results to define key pharmacokinetic (PK) and pharmacodynamic (PD) parameters. These data are intended to help design future trials of mTOR-targeting therapies for age-related conditions.
Who could benefit from this research
Good fit: Ideal candidates are adults aged 65 and older who are generally healthy without severe concurrent illnesses or medications that strongly interact with mTOR inhibitors.
Not a fit: People with active serious illnesses, organ transplants, or who take interacting medications may not be eligible and are unlikely to benefit from participation.
Why it matters
Potential benefit: If successful, the work could identify safer dosing and reliable biomarkers that make future mTOR-based treatments for older adults safer and more likely to show benefit.
How similar studies have performed: Animal and some clinical work suggest mTOR inhibitors can affect aging-related processes, but detailed PK/PD data in otherwise healthy older adults remain limited.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Timofte, Irina — Ut Southwestern Medical Center
- Study coordinator: Timofte, Irina
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.