Single versus multiple arterial grafts for women having coronary bypass
2/2- Randomized comparison of the Outcomes of single vs Multiple Arterial grafts trial in Women (ROMA:Women)
This trial compares using one artery graft versus multiple artery grafts during coronary artery bypass surgery in women to see which approach leads to fewer heart and brain problems and better quality of life.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11137278 on NIH RePORTER |
What this research studies
If you join, you would be randomly assigned to receive either a single arterial graft (with veins as needed) or multiple arterial grafts during your coronary bypass. The study aims to enroll about 2,000 women and will track major outcomes like death, stroke, heart attack, repeat procedures, and hospital readmissions. Researchers will also collect information on general and heart-specific quality of life and on physical and mental health symptoms after surgery. The trial uses the ROMA network, centralized database, and trained coordinators to manage enrollment and follow-up.
Who could benefit from this research
Good fit: Women aged 21 or older who are scheduled to undergo coronary artery bypass grafting for significant coronary artery disease are the intended candidates.
Not a fit: Men, people not undergoing CABG, or women whose anatomy or health makes multiple arterial grafting impossible would not be eligible and are unlikely to benefit directly from this trial.
Why it matters
Potential benefit: If successful, the results could guide surgeons to a grafting approach that lowers death, stroke, repeat procedures, and improves quality of life for women after CABG.
How similar studies have performed: Observational studies have linked multiple arterial grafting to better outcomes, but randomized evidence is limited and prior trials have been inconclusive, particularly for women.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Bagiella, Emilia — Icahn School of Medicine at Mount Sinai
- Study coordinator: Bagiella, Emilia
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.