Single versus multiple arterial grafts and memory after bypass surgery
Randomized Comparison of the Clinical Outcome of Single Versus Multiple Arterial Grafts: Cognition (ROMA:Cog)
This project compares whether using one or multiple arterial grafts during coronary bypass changes thinking and memory in adults having the surgery.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11467875 on NIH RePORTER |
What this research studies
If you join, you would be one of about 2,000 adults randomly assigned to receive either a single arterial graft or multiple arterial grafts during coronary artery bypass. The team will track your thinking, memory, and any signs of stroke or small brain infarcts over time using cognitive tests, active follow-up, and imaging when indicated. They will compare outcomes overall and in key groups such as women and people with diabetes to see if one surgical approach leads to fewer brain injuries or less cognitive decline. The goal is to detect even small changes after surgery and understand how surgical technique relates to postoperative brain health.
Who could benefit from this research
Good fit: Adults (21 years and older) scheduled for coronary artery bypass grafting who are eligible for either single or multiple arterial graft approaches would be ideal candidates.
Not a fit: People who are not having CABG, those under 21, or patients who are not eligible for one of the grafting techniques are unlikely to receive direct benefit from participating.
Why it matters
Potential benefit: If differences are found, surgeons could choose grafting techniques that reduce the risk of stroke and long-term thinking or memory problems after bypass.
How similar studies have performed: Smaller observational and imaging studies have linked aortic manipulation and graft technique to emboli and cognitive changes, but a large randomized comparison focused on cognition is relatively new.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Masterson Creber, Ruth Marie — Columbia University Health Sciences
- Study coordinator: Masterson Creber, Ruth Marie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.