Single-scan MRI to map brain tumor shape, blood flow, and oxygen levels
One-shot morphologic, hemodynamic and metabolic MR imaging of brain tumors
['FUNDING_R01'] · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · NIH-10892251
A single MRI scan with one contrast injection aims to show a brain tumor's size, blood flow, and oxygen (hypoxia) for people with brain tumors.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ARIZONA STATE UNIVERSITY-TEMPE CAMPUS (nih funded) |
| Locations | 1 site (SCOTTSDALE, UNITED STATES) |
| Trial ID | NIH-10892251 on ClinicalTrials.gov |
What this research studies
If I have a brain tumor, this approach would use one contrast-enhanced MRI scan to capture the tumor's shape, blood flow, and metabolic signs like low oxygen in one visit. The method combines routine contrast-enhanced MRI with dynamic imaging to create multiple maps from the same injection instead of separate PET scans. That could reduce the number of scans, injections, cost, and discomfort compared with current multi-modality imaging pathways. The team plans to validate that these combined maps reliably show features clinicians use for biopsy, surgery, radiation planning, and follow-up.
Who could benefit from this research
Good fit: Ideal candidates are adults with known or suspected brain tumors who are scheduled for clinical contrast-enhanced MRI for biopsy planning, surgery, radiation planning, or surveillance.
Not a fit: People who cannot have MRI or gadolinium-based contrast (for example due to certain implants, severe kidney failure, or pregnancy) may not be able to participate or benefit.
Why it matters
Potential benefit: If successful, doctors could see tumor perfusion and hypoxia during a single routine MRI, reducing extra scans and helping tailor surgery and radiation.
How similar studies have performed: Prior PET and multiparametric MRI studies have shown promise for measuring tumor blood flow and hypoxia, but combining those measurements into a single contrast-enhanced, one-shot MRI scan is relatively new and still under validation.
Where this research is happening
SCOTTSDALE, UNITED STATES
- ARIZONA STATE UNIVERSITY-TEMPE CAMPUS — SCOTTSDALE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KODIBAGKAR, VIKRAM D. — ARIZONA STATE UNIVERSITY-TEMPE CAMPUS
- Study coordinator: KODIBAGKAR, VIKRAM D.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.