Single-cell genomics to discover COVID-19 antibodies
CORE B: GENOMICS CORE
['FUNDING_OTHER'] · EMORY UNIVERSITY · NIH-11178444
Using advanced single-cell methods to find antibodies and map immune responses that target SARS-CoV-2 and its variants for people affected by COVID-19.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | EMORY UNIVERSITY (nih funded) |
| Locations | 1 site (ATLANTA, UNITED STATES) |
| Trial ID | NIH-11178444 on ClinicalTrials.gov |
What this research studies
This core develops and applies cutting-edge single-cell genomic tools that read immune cell RNA, antibody sequences, surface proteins, and chromatin state all at once. Researchers will use DNA barcoding and B cell receptor sequencing to pinpoint which B cells make antibodies that bind the spike protein from major SARS-CoV-2 variants. The core supports linked projects by processing patient-derived samples and producing detailed immune maps and antibody sequence data. Findings will help nominate antibodies for further testing and build a resource of immune information tied to different viral variants.
Who could benefit from this research
Good fit: Ideal participants are people who have had COVID-19 or been vaccinated and are willing to donate blood or other samples for immune profiling.
Not a fit: Patients seeking immediate treatment or clinical care are unlikely to receive direct benefit because the core supports laboratory research rather than offering therapies.
Why it matters
Potential benefit: If successful, this work could speed discovery of broadly neutralizing antibodies and improve therapies or vaccine strategies against current and future SARS-CoV-2 variants.
How similar studies have performed: Related single-cell and B cell receptor sequencing efforts have previously identified neutralizing antibodies for COVID-19 and other infections, making this a promising extension using more integrated methods.
Where this research is happening
ATLANTA, UNITED STATES
- EMORY UNIVERSITY — ATLANTA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: AHMED, RAFI — EMORY UNIVERSITY
- Study coordinator: AHMED, RAFI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.