Signals that strengthen memory-related brain connections
Effectors of presynaptic cAMP dependent potentiation at mossy fiber synapses
This project looks at how natural brain signals called cAMP and their partner proteins boost connections in the hippocampus to support memory, which could be relevant for people with Alzheimer’s disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-11141176 on NIH RePORTER |
What this research studies
From a patient’s viewpoint, the researchers are working in the lab to find the molecules that let cAMP strengthen specific memory circuits in the hippocampus. They will use advanced protein-mapping (proteomics), biochemical tests, and electrical recordings from brain tissue to identify key signaling partners. The team focuses on mossy fiber to CA3 synapses, a part of the hippocampus important for separating and retrieving memories. Results aim to reveal molecular targets that might be useful for future treatments.
Who could benefit from this research
Good fit: People with Alzheimer’s disease or mild cognitive impairment would be most relevant if the team requests patient samples or plans future clinical testing.
Not a fit: Patients seeking immediate treatment benefit are unlikely to gain direct help from this early laboratory research.
Why it matters
Potential benefit: If successful, this work could point to new drug targets to help preserve or restore memory in Alzheimer’s disease.
How similar studies have performed: Previous lab studies show cAMP-related proteins like PKA and Epac2 can alter synaptic strength, but the exact molecular steps at these mossy fiber synapses remain largely unproven and are the focus here.
Where this research is happening
Chicago, United States
- Northwestern University — Chicago, United States (Active)
Researchers
- Principal investigator: Contractor, Anis — Northwestern University
- Study coordinator: Contractor, Anis
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.