Short form of TET1 linked to myelodysplastic syndromes (MDS)
Role of the TET1 short isoform in MDS development and maintenance
['FUNDING_R01'] · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · NIH-11469145
Looks at whether a shorter version of the TET1 protein disrupts blood stem cells and contributes to myelodysplastic syndromes in people with or at risk for MDS.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BECKMAN RESEARCH INSTITUTE/CITY OF HOPE (nih funded) |
| Locations | 1 site (DUARTE, UNITED STATES) |
| Trial ID | NIH-11469145 on ClinicalTrials.gov |
What this research studies
Researchers will measure levels of the short TET1-S protein in bone marrow samples from people with MDS and from healthy donors to confirm its association with disease. They will test how TET1-S changes hematopoietic stem cell behavior using patient-derived cells and laboratory models. Molecular and genetic experiments will examine how TET1-S alters DNA methylation and gene activity to produce MDS-like changes. The team will use these results to look for biomarkers or molecular targets that could guide future diagnostics or treatments.
Who could benefit from this research
Good fit: Adults diagnosed with myelodysplastic syndromes or people with abnormal blood counts who are willing to provide bone marrow samples would be ideal candidates to inform this work.
Not a fit: People seeking immediate treatment changes or those without blood or bone marrow disorders are unlikely to receive direct medical benefit from this mechanistic research.
Why it matters
Potential benefit: Could reveal a new biomarker or therapeutic target that helps detect, prevent, or treat MDS in the future.
How similar studies have performed: Prior studies link TET family proteins to blood cancers and show TET1-S is upregulated in MDS, but the specific role of this short isoform remains largely unproven and is relatively novel.
Where this research is happening
DUARTE, UNITED STATES
- BECKMAN RESEARCH INSTITUTE/CITY OF HOPE — DUARTE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: QIAN, ZHIJIAN — BECKMAN RESEARCH INSTITUTE/CITY OF HOPE
- Study coordinator: QIAN, ZHIJIAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.