Shared tumor genome resource for osteosarcoma and leiomyosarcoma
Genome Characterization Unit
This project builds a shared database of clinical information, tumor genomes, and patient-reported data to help people with osteosarcoma and leiomyosarcoma.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Broad Institute, INC. NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project ID | NIH-11196734 on NIH RePORTER |
What this research studies
You would be invited to join one of two patient-facing projects (OSproject or LMSproject) where the team collects medical records, surveys, and tumor or blood samples through online consent and coordination. The samples will undergo genomic sequencing and computational analysis while clinical and patient-reported data are linked to those results. All data will be combined into a shared, searchable database to speed discovery of new treatment targets and trial opportunities. The project aims to enroll about 3,000 adult and pediatric participants over the grant period.
Who could benefit from this research
Good fit: People of any age diagnosed with osteosarcoma or leiomyosarcoma who can share medical records, provide tumor or blood samples, and complete questionnaires are ideal candidates.
Not a fit: People without osteosarcoma or leiomyosarcoma, or those unwilling or unable to provide samples or medical records, are unlikely to benefit directly from participation.
Why it matters
Potential benefit: If successful, this resource could reveal new treatment targets, improve diagnostic understanding, and support development of better trials and care for OS and LMS patients.
How similar studies have performed: Other patient-driven genomic initiatives have successfully uncovered new targets and matched patients to trials, but comprehensive shared genomic databases specifically for osteosarcoma and leiomyosarcoma remain limited.
Where this research is happening
Cambridge, United States
- Broad Institute, INC. — Cambridge, United States (Active)
Researchers
- Principal investigator: Gabriel, Stacey — Broad Institute, INC.
- Study coordinator: Gabriel, Stacey
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.