Shared osteosarcoma and leiomyosarcoma patient genomic database
Administrative Core
Adults and children with osteosarcoma or leiomyosarcoma are invited to join an online effort to share clinical information, tumor genomics, and patient-reported data to help find better treatments.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Broad Institute, INC. NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project ID | NIH-11196727 on NIH RePORTER |
What this research studies
If I join, I would use a website to consent and share my medical records, treatment history, and surveys, and I could submit tumor samples or sequencing data when available. The team plans to enroll up to 3,000 adult and pediatric participants and combine clinical, genomic, molecular, and patient-reported information into a single, shared database. Researchers at the Broad Institute will run computational analyses to look for genetic changes, patterns, and links to treatment responses that could point to new clinical trials or targeted therapies. The projects are patient-partnered and will work with advocacy groups and families in the osteosarcoma and leiomyosarcoma communities.
Who could benefit from this research
Good fit: Ideal candidates are adults or children diagnosed with osteosarcoma or leiomyosarcoma who can provide medical records and, when possible, tumor samples or genomic data.
Not a fit: People without osteosarcoma or leiomyosarcoma, or those unwilling or unable to share records or samples, are unlikely to receive direct benefits from this project.
Why it matters
Potential benefit: If successful, this shared database could speed discovery of targeted therapies, improve diagnostics, and increase opportunities for trials for OS and LMS patients.
How similar studies have performed: Other patient-partnered genomic efforts have produced useful discoveries in some cancers, but large shared databases specifically for osteosarcoma and leiomyosarcoma have been limited, so this approach is partly novel and promising.
Where this research is happening
Cambridge, United States
- Broad Institute, INC. — Cambridge, United States (Active)
Researchers
- Principal investigator: Wagle, Nikhil — Broad Institute, INC.
- Study coordinator: Wagle, Nikhil
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.