Shared decision tool to prevent dangerous drug interactions with blood thinners
Implementation of DDInteract: A Shared-decision Making Tool for Anticoagulant Drug-Drug INTERACTions
An EHR-embedded tool to help people on warfarin or DOACs and their clinicians spot and reduce risky drug interactions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Utah State Higher Education System--University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project ID | NIH-11123200 on NIH RePORTER |
What this research studies
As someone taking a blood thinner, I may also take other medicines that increase bleeding risk, and this project puts DDInteract inside the electronic health record so clinicians and patients can see personalized interaction risks during visits. The team will train clinicians to launch DDInteract during prescribing, present clear risk information, and guide conversations about safer alternatives. Researchers will track how often the tool is used, whether prescribing or medication combinations change, and whether exposure to important anticoagulant drug-drug interactions decreases. The project uses real-world EHR workflows and implementation-science methods to promote sustainable use of the tool.
Who could benefit from this research
Good fit: People taking warfarin or a DOAC (apixaban, dabigatran, edoxaban, rivaroxaban), especially those on multiple other medications or with atrial fibrillation or other clotting conditions, are the ideal candidates.
Not a fit: People not taking anticoagulants, those with no interacting medications, or patients who receive care outside participating health systems are unlikely to benefit directly.
Why it matters
Potential benefit: If successful, this could reduce patients' exposure to dangerous anticoagulant drug interactions and lower bleeding complications.
How similar studies have performed: Standard EHR drug-drug interaction alerts are common but nonspecific and often ignored, while this EHR-integrated shared-decision approach is newer and promising but still being tested in routine care.
Where this research is happening
Salt Lake City, United States
- Utah State Higher Education System--University of Utah — Salt Lake City, United States (Active)
Researchers
- Principal investigator: Malone, Daniel C — Utah State Higher Education System--University of Utah
- Study coordinator: Malone, Daniel C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.