Sex differences in how the body heals after radiation exposure
Official title: Sexual Dimorphism in repair and regeneration after radiation exposure
Funded at Albert Einstein College of Medicine · NIH-11323599 · Data updated 2026-11-12
This grant studies how biological sex affects recovery and treatment after radiation exposure to improve outcomes for people with Acute Radiation Syndrome.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albert Einstein College of Medicine NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project start | June 1, 2024 |
| Project end | April 30, 2027 |
| Funding year | 2026 |
| Award (this year) | $630,543 |
| NIH project number | 5U01AI183947-03 |
| Project ID | NIH-11323599 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are individuals at risk of radiation exposure or patients with radiation-induced injury, where sex-specific therapies could be beneficial in the future.
✕Less likely to help
This research uses animal models and is not a direct treatment for patients today; results would need translation before patient benefits.
What this research studies
Researchers will examine how male and female biology, including hormones and sex chromosomes, influence recovery from radiation damage to the blood and gut. They will use mouse models to compare survival, tissue damage, and molecular changes, including how IL-33 signaling may differ by sex. The study will look at how removing gonads and using a special four-core genotype helps separate hormone effects from chromosome effects. Data from survival, tissue analysis, metabolomics, and gene expression will guide potential new therapies. The goal is to tailor countermeasures to sex-specific biology in radiation injury.
Why it matters
Potential benefit: If successful, the work could lead to sex-specific treatments that improve survival and organ recovery after radiation exposure.
How similar studies have gone: Previous studies suggest sex differences exist in immune responses and recovery after injury, but this project directly tests SABV in radiation injury.
Where this research is happening
-
Albert Einstein College of Medicine
Bronx, United States Active
Researchers
- Principal investigator: Guha, Chandan — Albert Einstein College of Medicine
- Study coordinator: Guha, Chandan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.