Serotonin changes that cause L-DOPA-related involuntary movements
Official title: Interrogating Maladaptive Serotonin Raphe-Striatal Plasticity in L-DOPA-Induced Dyskinesia
Funded at State University of Ny,binghamton · NIH-11235114 · Data updated 2026-11-12
This project looks at how serotonin-related brain changes cause involuntary movements in people with Parkinson's who take L‑DOPA.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University of Ny,binghamton NIH-funded |
| Lab location | 1 site (Binghamton, United States) |
| Project start | December 1, 2021 |
| Project end | November 30, 2026 |
| Funding year | 2026 |
| Award (this year) | $605,799 |
| NIH project number | 5R01NS122226-05 |
| Project ID | NIH-11235114 on NIH RePORTER |
Who could benefit from this research
✓Could help
People with Parkinson's disease who experience L‑DOPA‑induced dyskinesia or who are starting L‑DOPA and are at risk for dyskinesia.
✕Less likely to help
People who do not take L‑DOPA, who have non‑Parkinsonian movement disorders, or whose symptoms come from other causes may not benefit from these findings.
What this research studies
If I have Parkinson's, this research uses animal models to trace how serotonin (5‑HT) neurons and the raphe‑to‑striatum circuit reorganize after L‑DOPA treatment and lead to dyskinesia. The team uses molecular tools, circuit mapping, and functional recordings to identify structural and functional changes in serotonin pathways that make involuntary movements worse. They compare these findings with prior data to pinpoint biological targets that could be modified to reduce or prevent dyskinesia. Ultimately this could guide future tests of drugs or other treatments aimed at preventing or easing L‑DOPA‑related involuntary movements.
Why it matters
Potential benefit: If successful, the work could point to new ways to prevent or reduce L‑DOPA‑induced involuntary movements for people with Parkinson's.
How similar studies have gone: Prior animal studies and some early clinical work implicate serotonin neurons in LID and have shown promise, but effective and widely applicable patient treatments remain limited.
Where this research is happening
-
State University of Ny,binghamton
Binghamton, United States Active
Researchers
- Principal investigator: Bishop, Christopher R — State University of Ny,binghamton
- Study coordinator: Bishop, Christopher R
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.