Sequencing and automated genetic mapping center for type 1 diabetes genes
Core B - Sequencing, Genotyping and Automated Mapping
['FUNDING_P01'] · UT SOUTHWESTERN MEDICAL CENTER · NIH-11096027
Using advanced DNA sequencing and automated mapping in mouse models, this project looks for single-gene changes that make type 1 diabetes worse or milder.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UT SOUTHWESTERN MEDICAL CENTER (nih funded) |
| Locations | 1 site (DALLAS, UNITED STATES) |
| Trial ID | NIH-11096027 on ClinicalTrials.gov |
What this research studies
Scientists will sequence DNA from specially bred mice that develop type 1 diabetes to find single-letter changes in genes. They will genotype many mice to see which mutations each mouse carries and use automated mapping plus powerful computers to link specific mutations with changes in diabetes development. Two different sequencing platforms are used to keep results very accurate, and any failed tests are rechecked by an alternate method. The goal is to find genes that either worsen or protect against type 1 diabetes so future treatments or tests can be developed.
Who could benefit from this research
Good fit: People living with brittle type 1 diabetes who want to follow genetic discoveries or be considered for future related studies would be the most relevant audience.
Not a fit: People with type 2 diabetes or non-autoimmune forms of high blood sugar are unlikely to directly benefit from this mouse-based genetic mapping project.
Why it matters
Potential benefit: If successful, this work could pinpoint genes that lead to new tests or therapies for people with brittle type 1 diabetes.
How similar studies have performed: Previous genetic mapping in mouse models has successfully identified genes that influence type 1 diabetes, and this project applies established sequencing and automated mapping methods to speed discovery.
Where this research is happening
DALLAS, UNITED STATES
- UT SOUTHWESTERN MEDICAL CENTER — DALLAS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BEUTLER, BRUCE A — UT SOUTHWESTERN MEDICAL CENTER
- Study coordinator: BEUTLER, BRUCE A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Brittle Diabetes Mellitus