Sensor-like LC-MS platform for real-time monitoring of small molecules in biological systems
Official title: Sensor-Like LC-MS Platform for Rapid Online Monitoring of Metabolites in Biological Systems
Funded at Rowan University · NIH-11361635 · Data updated 2026-11-12
A new LC-MS tool is being developed to measure multiple small-molecule metabolites in real time, aiming to help scientists understand how biological systems communicate.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rowan University NIH-funded |
| Lab location | 1 site (Glassboro, United States) |
| Project start | September 15, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2026 |
| Award (this year) | $375,000 |
| NIH project number | 5R35GM154693-03 |
| Project ID | NIH-11361635 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are individuals whose conditions involve metabolic or signaling pathways affected by small-molecule metabolites and who may participate through future translational studies or related biospecimen efforts.
✕Less likely to help
Patients whose conditions do not involve detectable metabolites or signaling pathways may see little direct benefit.
What this research studies
This project creates a miniaturized, fast LC-MS system that can track several metabolites at once with high speed. It uses a specialized online derivatization device and a segmented-flow droplet approach to boost precision and temporal resolution. The goal is a ready-to-use platform that can deliver measurements every 10-15 seconds, enabling closer observation of dynamic biological processes.
Why it matters
Potential benefit: If successful, patients could benefit from faster, more accurate metabolic readouts that inform diagnosis and treatment decisions.
How similar studies have gone: Prior platforms have shown improved real-time metabolite monitoring, with the current approach aiming to significantly increase throughput and temporal resolution.
Where this research is happening
-
Rowan University
Glassboro, United States Active
Researchers
- Principal investigator: Grinias, James P — Rowan University
- Study coordinator: Grinias, James P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.