Self-healing, regenerative vascular grafts for kidney dialysis patients
Official title: Engineering Self-healing, Cell-free and Regenerating Vascular Grafts
Funded at State University of New York at Buffalo · NIH-11444224 · Data updated 2026-11-12
A new vascular graft technology aims to provide durable, self-healing grafts for people needing hemodialysis, reducing complications and cannulation-related problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University of New York at Buffalo NIH-funded |
| Lab location | 1 site (Amherst, United States) |
| Project start | August 20, 2026 |
| Project end | April 30, 2030 |
| Funding year | 2026 |
| Award (this year) | $740,447 |
| NIH project number | 1R01HL184001-01A1 |
| Project ID | NIH-11444224 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are adults with end-stage renal disease requiring hemodialysis access or those who could benefit from improved vascular graft options.
✕Less likely to help
Patients not requiring vascular grafts or with conditions limiting graft use may not benefit.
What this research studies
This project develops acellular tissue-engineered vessels that mimic natural endothelium and can repair themselves after repeated needle cannulations. The work builds on prior animal studies to create grafts with mechanical strength and seamless integration with blood vessels. The goals are to make grafts that stay patent longer and reduce bleeding, pseudoaneurysm, and thrombosis risks for people with ESRD. The research combines biomaterials, tissue engineering, and translational steps toward human use.
Why it matters
Potential benefit: If successful, patients on hemodialysis could have longer-lasting vascular grafts that are easier to cannulate and result in fewer complications.
How similar studies have gone: Previous animal studies show promising patency and integration of these grafts, suggesting potential for human translation.
Where this research is happening
-
State University of New York at Buffalo
Amherst, United States Active
Researchers
- Principal investigator: Andreadis, Stelios T. — State University of New York at Buffalo
- Study coordinator: Andreadis, Stelios T.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.