Seeing how cells and tissues react to stress in diseases like Alzheimer's and cancer
An Activity-Based Biomolecule Labeling Platform for the Imaging of Cells and Tissues Under Oxidative Stress
['FUNDING_OTHER'] · UNIVERSITY OF DELAWARE · NIH-11158908
This research is creating new ways to see how stress affects cells and tissues, which could help us understand diseases like Alzheimer's and cancer better.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF DELAWARE (nih funded) |
| Locations | 1 site (Newark, UNITED STATES) |
| Trial ID | NIH-11158908 on ClinicalTrials.gov |
What this research studies
Our bodies naturally produce small molecules called reactive oxygen species (ROS) that play roles in both healthy cell signaling and harmful stress. When ROS production goes wrong, it can contribute to serious conditions like Alzheimer's disease and various cancers. Currently, it's hard to accurately see where and when these molecules are active in cells. This project aims to develop special fluorescent tools that can permanently record the activity of ROS, allowing scientists to get a clearer picture of their role in disease. By improving how we visualize these processes, we hope to unlock new insights into how these diseases develop.
Who could benefit from this research
Good fit: Patients with conditions linked to oxidative stress, such as Alzheimer's disease or various cancers, could eventually benefit from the insights gained through this foundational research.
Not a fit: Patients seeking immediate treatment options or direct clinical intervention would not directly benefit from this basic science research.
Why it matters
Potential benefit: If successful, this work could provide researchers with a powerful new tool to better understand the fundamental causes of diseases like Alzheimer's and cancer, potentially leading to new treatment strategies.
How similar studies have performed: This project proposes a novel approach to create cell-trappable fluorescent probes for permanent recording of ROS activity, building on existing fluorescence microscopy techniques but addressing their limitations.
Where this research is happening
Newark, UNITED STATES
- UNIVERSITY OF DELAWARE — Newark, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MESSINA, MARCO — UNIVERSITY OF DELAWARE
- Study coordinator: MESSINA, MARCO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease, Cancers