Salt in the Skin and Eczema
Sodium in the Skin and Atopic Dermatitis: The SIS-AD Study
This project tests whether high salt in the diet and skin makes atopic dermatitis worse and whether lowering salt can help people with eczema.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-11187118 on NIH RePORTER |
What this research studies
From a patient's perspective, researchers will measure how much sodium is stored in the skin and track participants' salt intake and skin barrier health. They will compare skin sodium levels with eczema severity and how long symptoms last. The team will look at whether people with higher skin sodium have more inflammation linked to atopic dermatitis. They will also explore if reducing dietary salt or skin sodium storage could improve symptoms.
Who could benefit from this research
Good fit: People with atopic dermatitis who can complete dietary tracking and attend skin testing visits, including outreach to Black/African American participants, are the ideal candidates.
Not a fit: People without atopic dermatitis or those whose eczema is unlikely driven by salt-related inflammation may not see benefit from this approach.
Why it matters
Potential benefit: If successful, this work could point to simple changes like lowering salt intake to ease eczema symptoms for some patients.
How similar studies have performed: Previous studies link skin sodium and inflammation, but applying this idea specifically to atopic dermatitis and testing dietary reduction is a relatively new approach.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Abuabara, Katrina Elaine — University of California, San Francisco
- Study coordinator: Abuabara, Katrina Elaine
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.