Saliva-protein denture coatings to prevent fungal growth
Salivary peptide/protein-based multilayer denture coatings for controlling Candida biofilm formation and denture stomatitis
['FUNDING_R01'] · UNIVERSITY OF MASSACHUSETTS LOWELL · NIH-11311877
Using saliva-based proteins applied to dentures to prevent Candida buildup and help denture wearers avoid denture stomatitis.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MASSACHUSETTS LOWELL (nih funded) |
| Locations | 1 site (LOWELL, UNITED STATES) |
| Trial ID | NIH-11311877 on ClinicalTrials.gov |
What this research studies
You would get dentures coated with natural saliva proteins that are layered to hold antifungal molecules like histatin-5 in place. The team will test these coatings on denture materials in the lab to see if they stop Candida biofilms, remain durable, and keep the denture comfortable and functional. Earlier lab work showed better binding of anticandidal molecules without harming denture properties, and this project aims to optimize coating stability and antifungal activity for real-world use. If everything works, the coating could reduce repeat infections and the need for repeated antifungal treatments.
Who could benefit from this research
Good fit: Ideal candidates are people who wear removable dentures and have recurrent denture stomatitis or are at high risk (for example older adults or those with weakened immune systems).
Not a fit: People who do not wear dentures, whose oral issues are caused by non-Candida organisms, or who are allergic to coating components are unlikely to benefit from this approach.
Why it matters
Potential benefit: If successful, this could lower Candida biofilms on dentures and reduce recurrent denture stomatitis, especially for elderly or immune-compromised denture wearers.
How similar studies have performed: Laboratory and materials studies have shown promising antifungal activity and improved protein binding, but clinical effectiveness in people has not yet been established.
Where this research is happening
LOWELL, UNITED STATES
- UNIVERSITY OF MASSACHUSETTS LOWELL — LOWELL, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SUN, YUYU — UNIVERSITY OF MASSACHUSETTS LOWELL
- Study coordinator: SUN, YUYU
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.