Saliva-based screening program for throat (oropharyngeal) cancer in the Southwest
Southwest EDRN Clinical Validation Center for Head and Neck Cancer
['FUNDING_U01'] · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · NIH-11140436
This project will use saliva tests for HPV and related antibodies to help find throat (oropharyngeal) cancers earlier in people at risk.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ARIZONA STATE UNIVERSITY-TEMPE CAMPUS (nih funded) |
| Locations | 1 site (SCOTTSDALE, UNITED STATES) |
| Trial ID | NIH-11140436 on ClinicalTrials.gov |
What this research studies
You would be invited to sign up digitally and provide self-collected saliva samples that are mailed or given at clinics. Your samples would be analyzed in a central CLIA/CAP laboratory for HPV DNA and multiplex antibody panels. The program is designed to run as a blinded, prospective validation to confirm how well these markers predict oropharyngeal cancer. If a test comes back positive, there are predefined clinical follow-up plans to guide next steps.
Who could benefit from this research
Good fit: Adults at higher risk for HPV-related oropharyngeal cancer or those willing to provide saliva samples and participate via digital enrollment are the ideal candidates.
Not a fit: People without risk factors for HPV-related throat cancer or those unable to provide saliva samples or follow-up care are unlikely to benefit directly from this project.
Why it matters
Potential benefit: If successful, validated saliva tests could catch HPV-related throat cancers earlier using a simple, noninvasive sample.
How similar studies have performed: Earlier phase 2 multicenter work showed promising HPV serologic biomarker signals, but this effort aims to confirm those findings in larger, blinded prospective validation.
Where this research is happening
SCOTTSDALE, UNITED STATES
- ARIZONA STATE UNIVERSITY-TEMPE CAMPUS — SCOTTSDALE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ANDERSON, KAREN SUE — ARIZONA STATE UNIVERSITY-TEMPE CAMPUS
- Study coordinator: ANDERSON, KAREN SUE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.