Safer stored blood for emergency trauma transfusions
Improving red blood cell storage for trauma resusciation
['FUNDING_OTHER'] · UNIVERSITY OF CINCINNATI · NIH-11090870
This project seeks ways to make stored blood safer for people who need emergency transfusions after serious injuries.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CINCINNATI (nih funded) |
| Locations | 1 site (CINCINNATI, UNITED STATES) |
| Trial ID | NIH-11090870 on ClinicalTrials.gov |
What this research studies
If I or someone I love needs emergency blood after a traumatic bleed, researchers will study what components of stored packed red blood cells cause inflammation, organ injury, and clotting. They will examine microparticles and other biochemical and physical changes that arise during storage and test approaches to reduce or neutralize those harmful elements. The team will use samples from stored blood and laboratory and preclinical models of hemorrhage and resuscitation to measure inflammatory and organ-injury responses. Findings will be used to guide changes in how blood is stored and prepared so transfusions cause less harm.
Who could benefit from this research
Good fit: People with severe traumatic bleeding who require rapid, multiple units of packed red blood cell transfusions, such as hemorrhagic shock patients at trauma centers.
Not a fit: Patients receiving small-volume, elective, or chronic transfusions for non-traumatic conditions may not directly benefit from this work.
Why it matters
Potential benefit: Could reduce complications such as organ failure, infection, and death after massive transfusions by making stored blood less inflammatory and damaging.
How similar studies have performed: Prior laboratory and animal work shows microparticles and storage-related components can drive inflammation and that removing or neutralizing them can reduce injury, but clear benefits in human trauma patients remain unproven.
Where this research is happening
CINCINNATI, UNITED STATES
- UNIVERSITY OF CINCINNATI — CINCINNATI, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PRITTS, TIMOTHY A — UNIVERSITY OF CINCINNATI
- Study coordinator: PRITTS, TIMOTHY A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.