RUNX proteins influence male reproductive cell development
Official title: RUNX proteins define opposing fates in the male germline
Funded at Washington State University · NIH-11164617 · Data updated 2026-11-12
This study is looking at how certain proteins help create the cells that are important for male fertility, and it aims to find out what goes wrong when these processes don't work right, which could lead to infertility or other health issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington State University NIH-funded |
| Lab location | 1 site (Pullman, United States) |
| Project start | August 15, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $393,998 |
| NIH project number | 5R01HD113747-02 |
| Project ID | NIH-11164617 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are males under 21 years old who may be experiencing issues related to fertility or developmental disorders.
✕Less likely to help
Patients who are not male or those over the age of 21 may not receive direct benefits from this research.
What this research studies
This research investigates how RUNX proteins affect the formation of germline stem cells in males, which are crucial for fertility. By utilizing advanced single-cell analysis techniques, the study aims to identify the key factors that regulate the development of these stem cells. Understanding these processes could reveal how disruptions in germline development can lead to infertility and other diseases later in life. The research focuses on the early stages of male reproductive cell development to uncover the mechanisms that ensure proper cell lineage formation.
Why it matters
Potential benefit: If successful, this research could lead to new insights into male infertility and potential therapeutic strategies to address it.
How similar studies have gone: Previous research has shown promising results in understanding stem cell development through similar molecular approaches, indicating potential for success in this area.
Where this research is happening
-
Washington State University
Pullman, United States Active
Researchers
- Principal investigator: Law, Nathan C. — Washington State University
- Study coordinator: Law, Nathan C.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.