Route 66 Endometrial Cancer Program
Route 66 Endometrial Cancer SPORE
['FUNDING_OTHER'] · WASHINGTON UNIVERSITY · NIH-11191494
This program develops and tries new treatments and prevention approaches for people with endometrial cancer and for women at high risk of the disease.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WASHINGTON UNIVERSITY (nih funded) |
| Locations | 1 site (SAINT LOUIS, UNITED STATES) |
| Trial ID | NIH-11191494 on ClinicalTrials.gov |
What this research studies
You would be invited to join a multi-center effort that brings lab discoveries into patient care through three coordinated projects and shared support cores. Two projects focus on new therapies for advanced or recurrent endometrial cancer by targeting HSPA proteins and blocking AXL, while the third focuses on preventing cancer and preserving the uterus in premenopausal women with obesity and abnormal uterine cells. The program runs clinical trials, collects tissue and blood samples, and uses biostatistics and bioinformatics to analyze data. Depending on the project, you might enroll in a trial, provide biospecimens, or take part in prevention and follow-up programs.
Who could benefit from this research
Good fit: Ideal candidates include people with advanced or recurrent endometrial cancer for the therapy trials and premenopausal women with obesity and endometrial hyperplasia for the prevention project.
Not a fit: People without endometrial disease or whose condition does not meet specific trial eligibility (for example other cancer types or unmatched stages) may not receive direct benefit from these projects.
Why it matters
Potential benefit: If successful, this work could improve treatment responses, reduce progression to cancer in high-risk women, and expand options for uterine preservation.
How similar studies have performed: Early lab work and some small clinical studies suggest AXL and HSPA-targeting approaches are promising but still experimental, and prevention strategies in obese premenopausal women need more clinical evidence.
Where this research is happening
SAINT LOUIS, UNITED STATES
- WASHINGTON UNIVERSITY — SAINT LOUIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MUTCH, DAVID G — WASHINGTON UNIVERSITY
- Study coordinator: MUTCH, DAVID G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.