Rotavirus Vaccine Failure and Gut Bacteria
Intestinal microbiota-mediated rotavirus vaccine failure
['FUNDING_R01'] · GEORGIA STATE UNIVERSITY · NIH-11143856
This project looks at how gut bacteria might cause rotavirus vaccines to not work as well in children.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | GEORGIA STATE UNIVERSITY (nih funded) |
| Locations | 1 site (ATLANTA, UNITED STATES) |
| Trial ID | NIH-11143856 on ClinicalTrials.gov |
What this research studies
Rotavirus vaccines protect many children each year, but they don't always work as well, especially in some parts of the world. We believe that the tiny bacteria living in a child's gut, called microbiota, play a big role in how well the vaccine protects them. Our past work shows that these gut bacteria can directly affect the rotavirus and also change the gut lining, making it harder for the vaccine to work. We are working to find out which specific gut bacteria cause the vaccine to be less effective and how they do it.
Who could benefit from this research
Good fit: Children, particularly infants and young children who receive rotavirus vaccines, are the focus of this research.
Not a fit: Patients who are not in the age range for rotavirus vaccination or who do not receive the vaccine would not directly benefit from this specific research.
Why it matters
Potential benefit: This work could help create better rotavirus vaccines or new ways to make existing vaccines more effective for all children.
How similar studies have performed: Previous work by this team and others has shown that gut bacteria can influence how well vaccines work, suggesting a promising direction for this research.
Where this research is happening
ATLANTA, UNITED STATES
- GEORGIA STATE UNIVERSITY — ATLANTA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GEWIRTZ, ANDREW T — GEORGIA STATE UNIVERSITY
- Study coordinator: GEWIRTZ, ANDREW T
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.