Roles of Biotransformation in Arsenic-Linked Anemia
Official title: Defining the Roles of Biotransformation in Arsenic-Induced Hematotoxicity
Funded at University of New Mexico Health Scis Ctr · NIH-11506801 · Data updated 2026-11-12
This grant explores how arsenic processing in the body leads to anemia by disrupting early blood cell development and identifying who might be at risk.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of New Mexico Health Scis Ctr NIH-funded |
| Lab location | 1 site (Albuquerque, United States) |
| Project start | July 1, 2020 |
| Project end | April 30, 2030 |
| Funding year | 2026 |
| Award (this year) | $211,119 |
| NIH project number | 5P20GM130422-07 |
| Project ID | NIH-11506801 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals with chronic arsenic exposure or arsenic-related hematologic problems, and researchers studying arsenic metabolism and blood cell formation.
✕Less likely to help
People without arsenic exposure or hematologic symptoms may not directly benefit.
What this research studies
Researchers will study how arsenic is transformed in the body and how these metabolic steps affect the formation of red blood cells, focusing on key transcription factors like GATA-1 and GATA-2. The work includes examining the liver’s role in producing a reactive arsenic metabolite and how this metabolite accumulates in bone marrow to disrupt blood cell development. By linking biotransformation with tissue distribution and transcriptional changes, the project aims to map the pathways that drive hematopoietic dysfunction in exposed individuals. Findings could clarify who is most at risk and guide strategies to prevent or mitigate anemia in populations with arsenic exposure.
Why it matters
Potential benefit: Understanding these mechanisms could lead to targeted prevention and treatment strategies for arsenic-related anemia.
How similar studies have gone: Prior studies have connected arsenic exposure to anemia and identified GATA factors as disrupted, but this project advances understanding of biotransformation and tissue-specific effects.
Where this research is happening
-
University of New Mexico Health Scis Ctr
Albuquerque, United States Active
Researchers
- Principal investigator: Medina, Sebastian — University of New Mexico Health Scis Ctr
- Study coordinator: Medina, Sebastian
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.