Role of reactive oxygen species in controlling T. gondii acute infection
Funded at California State Poly U Pomona · NIH-11374983 · Data updated 2026-11-12
This project looks at how immune cells called neutrophils fight the parasite Toxoplasma gondii by producing reactive oxygen species during acute infection.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | California State Poly U Pomona NIH-funded |
| Lab location | 1 site (Pomona, United States) |
| Project start | July 24, 2024 |
| Project end | June 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $182,896 |
| NIH project number | 5R16AI184345-03 |
| Project ID | NIH-11374983 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideally, individuals with or at risk for toxoplasmosis or with immunocompromised status may benefit from future applications of this work.
✕Less likely to help
Healthy individuals with no exposure or risk may not receive direct benefit.
What this research studies
If you have a Toxoplasma infection or are pregnant or immunocompromised, understanding how neutrophils use reactive oxygen to control the parasite could lead to new treatments. The study will identify the cellular steps and receptors that trigger reactive oxygen production in infected neutrophils and determine whether this killing relies on the Nox2 pathway or other sources. It involves laboratory research using human cells to uncover mechanisms that protect against acute toxoplasmosis. Results could inform future therapies or vaccines for people at risk.
Why it matters
Potential benefit: Findings could guide the development of therapies to boost the body's innate defense against T. gondii and reduce severe illness in vulnerable individuals.
How similar studies have gone: Previous work shows neutrophil ROS play a role in fighting infections, but the exact mechanisms with T. gondii are not fully understood, making this a promising but early-stage study.
Where this research is happening
-
California State Poly U Pomona
Pomona, United States Active
Researchers
- Principal investigator: Lima, Tatiane S. — California State Poly U Pomona
- Study coordinator: Lima, Tatiane S.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.