Role of IL-9 in gastric metaplasia and cancer development
Official title: The role of IL-9 in gastric metaplasia and carcinogenesis
Funded at Saint Louis University · NIH-11448151 · Data updated 2026-11-12
Scientists are studying how immune signals in the stomach, especially IL-9, may drive precancerous changes and stomach cancer, using mouse models, organoids, and human tissue to understand risk and new ways to diagnose or treat the disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Saint Louis University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | September 21, 2026 |
| Project end | August 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $2,541,122 |
| NIH project number | 1R01CA325465-01A1 |
| Project ID | NIH-11448151 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are people at risk for gastric cancer or with gastric metaplasia who may benefit from improved risk assessment or future immune-targeted therapies.
✕Less likely to help
People without gastric inflammation or metaplasia or those not involved in future diagnostic or therapeutic developments may not directly benefit.
What this research studies
This project uses advanced mouse models and lab-grown organoids to examine how inflammation and the immune system promote pyloric and intestinal metaplasia, which can lead to gastric cancer. It also analyzes human tissue to bridge findings from animals to people. By mapping the specific immune cells and cytokines involved, researchers hope to identify markers of high cancer risk and potential immune-based therapies. The work combines genetic models, cytokine treatments, and tissue samples to study the sequence from inflammation to cancer in the stomach. Results could improve risk prediction and create new approaches to prevention and treatment for gastric cancer.
Why it matters
Potential benefit: If successful, the research could lead to better prediction of who is at high risk for gastric cancer and inform new immune-based strategies to diagnose and treat it.
How similar studies have gone: Previous studies show that inflammation and immune signals can influence gastric metaplasia, with potential for similar immune-targeted approaches, making this an important but evolving area.
Where this research is happening
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Saint Louis University
Saint Louis, United States Active
Researchers
- Principal investigator: Dipaolo, Richard J — Saint Louis University
- Study coordinator: Dipaolo, Richard J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.