Role of GRIN2 in ART and substance-use related brain effects
Official title: Role of GRIN2 in ART and SUD associated neurological deficits.
Funded at Meharry Medical College · NIH-11387861 · Data updated 2026-11-12
A researcher at Meharry Medical College is studying how HIV treatment and cocaine use together affect brain function and nerve cells.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Meharry Medical College NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project start | September 15, 2022 |
| Project end | August 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $726,919 |
| NIH project number | 5R01DA057204-05 |
| Project ID | NIH-11387861 on NIH RePORTER |
Who could benefit from this research
✓Could help
People living with HIV who are on INSTI-based ART and have a history of cocaine use.
✕Less likely to help
HIV patients not on INSTI-based ART and without substance-use history may not benefit directly.
What this research studies
This project looks at how antiretroviral therapy, especially INSTIs, interacts with chronic cocaine use to influence neuronal health in people living with HIV. It uses lab models and patient-derived information to explore the combined impact on brain cells and related neuropsychiatric symptoms. The aim is to identify mechanisms behind observed side effects and to lay groundwork for safer ART options for patients who use cocaine.
Why it matters
Potential benefit: If successful, findings could lead to safer HIV treatments with fewer neuropsychiatric side effects for patients who use cocaine.
How similar studies have gone: Previous studies have shown ART-related neuropsychiatric effects; this work builds on those findings with a focus on INSTI and cocaine interaction.
Where this research is happening
-
Meharry Medical College
Nashville, United States Active
Researchers
- Principal investigator: Dash, Chandravanu — Meharry Medical College
- Study coordinator: Dash, Chandravanu
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.