RNA-Protein Interactions in Genome Regulation and Aging
Official title: Structural transitions and RNA-mediated mechanisms of LSD1
Funded at Marquette University · NIH-11372899 · Data updated 2026-11-12
A study at Marquette University will look at how RNA structures and RNA-binding proteins interact with LSD1 to influence genome stability, aging, cancer spread, and neural development.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Marquette University NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project start | August 15, 2017 |
| Project end | July 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $417,188 |
| NIH project number | 5R01GM120572-10 |
| Project ID | NIH-11372899 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not applicable for this grant as described (basic biochemistry and molecular biology study).
✕Less likely to help
No direct patient participation or benefit is described in the grant as funded.
What this research studies
This project explores how non-coding RNAs and RNA-protein interactions influence how DNA packaging works in cells. Researchers will study how RNA can mimic DNA, form hybrids, and recruit protein complexes to chromatin, potentially changing gene activity. They will examine how RNA-protein networks form condensates in a cell-like environment and how these changes affect the function of the LSD1 enzyme. The work aims to map the features of RNA that drive these interactions and what RNA-protein changes mean for genome regulation.
Why it matters
Potential benefit: If successful, the work could reveal new ways that RNA and LSD1 regulate genes, potentially guiding future strategies to address aging and cancer progression.
How similar studies have gone: Previous research shows RNA-protein assemblies can regulate chromatin, with emerging evidence in gene regulation and disease contexts.
Where this research is happening
-
Marquette University
Milwaukee, United States Active
Researchers
- Principal investigator: Reiter, Nicholas J — Marquette University
- Study coordinator: Reiter, Nicholas J
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.