RNA-binding proteins and workplace chemical–linked liver injury
Modulation of RNA Binding Proteins in Xenobiotic-induced Hepatotoxicity
['FUNDING_R01'] · NORTH CAROLINA STATE UNIVERSITY RALEIGH · NIH-11014030
This research looks at how proteins that control RNA affect liver damage from workplace chemicals to help people exposed to those substances.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NORTH CAROLINA STATE UNIVERSITY RALEIGH (nih funded) |
| Locations | 1 site (RALEIGH, UNITED STATES) |
| Trial ID | NIH-11014030 on ClinicalTrials.gov |
What this research studies
Researchers will study proteins in the TTP family that help cells control inflammation-related messages, using lab models, molecular experiments, and computer (bioinformatics) analyses. They will expose cells and animal models to common industrial chemicals known to harm the liver and track how these RNA-binding proteins change and contribute to inflammation and scarring. The team will search for biological markers of early chemical-induced liver injury and identify protein targets that might be blocked to reduce inflammation and fibrosis. Ultimately the work aims to point toward tests or treatments that could protect workers and others exposed to liver-toxic chemicals.
Who could benefit from this research
Good fit: People with a history of occupational or environmental exposure to liver-toxic chemicals or with early signs of chemically related liver inflammation or fibrosis would be most relevant to this work.
Not a fit: People whose liver disease is solely due to causes unrelated to chemical exposures, such as hereditary metabolic disorders, may not benefit directly from these findings.
Why it matters
Potential benefit: If successful, this work could point to new tests to spot early chemical-related liver damage and to treatments that reduce inflammation and scarring.
How similar studies have performed: Prior lab and human tumor studies have linked TTP-family RNA-binding proteins to liver cancer and shown that certain chemicals alter these proteins, but applying that knowledge to prevent or treat chemical-induced liver injury is a newer direction.
Where this research is happening
RALEIGH, UNITED STATES
- NORTH CAROLINA STATE UNIVERSITY RALEIGH — RALEIGH, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SAINI, YOGESH — NORTH CAROLINA STATE UNIVERSITY RALEIGH
- Study coordinator: SAINI, YOGESH
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.