RNA and tumor genomics analysis center
Specialized RNA analysis center for integrative genomic analyses
This project uses RNA and other tumor genetic data from cancer patients to improve how tumors are grouped and linked to treatment outcomes.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project ID | NIH-11169902 on NIH RePORTER |
What this research studies
This UNC team analyzes RNA sequencing and spatial transcriptomics from tumor samples and combines those results with other genomic data to better define tumor subtypes. They develop and apply methods to normalize data, integrate multiple data types, and search for biomarkers tied to clinical outcomes. The center will work with samples from clinical trials such as ALCHEMIST and the Clinical Trials Sequencing Program so findings can connect back to patient care. Their analyses aim to produce clearer tumor classifications and molecular signatures that could inform treatment decisions.
Who could benefit from this research
Good fit: Ideal participants are people with cancer who provide tumor samples or enroll in linked clinical trials (for example ALCHEMIST or the Clinical Trials Sequencing Program).
Not a fit: Patients without tumor sequencing data or whose cancers are not part of the trials tied to this work are less likely to see direct benefits.
Why it matters
Potential benefit: If successful, this work could help doctors choose more precise treatments by improving tumor classification and identifying new biomarkers.
How similar studies have performed: Large efforts such as The Cancer Genome Atlas have shown RNA and integrative genomics can classify tumors and reveal clinically useful biomarkers, so this builds on established approaches.
Where this research is happening
Chapel Hill, United States
- Univ of North Carolina Chapel Hill — Chapel Hill, United States (Active)
Researchers
- Principal investigator: Hoadley, Katherine a. — Univ of North Carolina Chapel Hill
- Study coordinator: Hoadley, Katherine a.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.