RNA and RNA-binding proteins on cell surfaces in cancer
Functional characterization of cell surface RNA biology
Researchers are exploring how RNA and RNA-binding proteins on the surface of cancer cells act and how that could affect people with cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11181537 on NIH RePORTER |
What this research studies
This project studies unusual RNAs and RNA-binding proteins that are found on the outside of cells, especially in cancer. The team will examine the molecular, biochemical, and biophysical behavior of these molecules and how they get trafficked to the cell surface. They will use biochemical assays, genetic screens, and cellular models to map functions and delivery pathways. The work will also develop technical tools and conceptual foundations to enable further study of cell-surface RNA biology.
Who could benefit from this research
Good fit: People with cancer whose tumors or blood samples can be accessed for research, or who are willing to donate tissue, would be the most relevant candidates for related studies.
Not a fit: Patients seeking immediate changes to their treatment are unlikely to benefit directly because this is early-stage, laboratory-focused research.
Why it matters
Potential benefit: If successful, this work could reveal new cancer biomarkers or surface targets that lead to improved diagnostics or future therapies.
How similar studies have performed: Molecular approaches have identified useful surface biomarkers in other settings, but the study of glycosylated RNAs on the cell surface is largely novel and not yet well tested.
Where this research is happening
Boston, United States
- Boston Children's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Flynn, Ryan Alexander — Boston Children's Hospital
- Study coordinator: Flynn, Ryan Alexander
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.