Rhesus monkey resource to speed safer gene and regenerative therapies for inherited diseases
Translational Nonhuman Primate Regenerative Medicine and Gene Therapy/Genome Editing Resource Program
This program builds and shares a rhesus monkey resource so scientists can develop safer gene and cell therapies for people with inherited disorders.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project ID | NIH-11235133 on NIH RePORTER |
What this research studies
From my point of view, researchers will use rhesus monkeys to improve and validate tools that better mimic human biology so new gene and cell therapies can be tested for safety. The program will refine methods to study human blood-forming cells inside the monkey model and develop technologies relevant across many organs. It will also generate data needed to move promising approaches toward human testing and regulatory (IND) studies. The resource is shared with other scientists to help speed multiple therapies toward clinical trials.
Who could benefit from this research
Good fit: People with inherited genetic disorders affecting organs such as blood, muscle, or other systems could be the kinds of patients who might benefit or be candidates for future trials informed by this work.
Not a fit: Patients with conditions unrelated to inherited genetic disorders or those needing non–gene-based treatments are unlikely to see direct short-term benefits from this program.
Why it matters
Potential benefit: If successful, this could make gene and cell therapies safer and more likely to reach human clinical trials for a range of inherited diseases.
How similar studies have performed: Nonhuman primate studies have previously helped predict safety for human gene therapies and some approaches have progressed to human trials, but a centralized resource like this is less common.
Where this research is happening
Davis, United States
- University of California at Davis — Davis, United States (Active)
Researchers
- Principal investigator: Tarantal, Alice F — University of California at Davis
- Study coordinator: Tarantal, Alice F
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.