Reversing ovarian aging in mice using gene therapy
Official title: Reversal of Ovarian Aging in Mice Through AAV-mediated Oocyte Reprogramming in vivo
Funded at Beth Israel Deaconess Medical Center · NIH-10723227 · Data updated 2026-11-12
This study is exploring a new way to help older women improve their fertility by using a special gene therapy to rejuvenate their egg cells, aiming to restore their reproductive health as they age.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beth Israel Deaconess Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $495,949 |
| NIH project number | 1R21AG083421-01 |
| Project ID | NIH-10723227 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are women of advanced reproductive age who are experiencing infertility or related reproductive challenges.
✕Less likely to help
Patients who are not of advanced reproductive age or those without fertility issues may not benefit from this research.
What this research studies
This research investigates how to reverse the aging process in ovarian cells, specifically focusing on oocytes, which are crucial for female fertility. By using a gene therapy technique called AAV-mediated oocyte reprogramming, the study aims to restore normal reproductive function in aging ovaries. The approach involves understanding the genetic and epigenetic factors that contribute to oocyte dysfunction as women age, with the goal of developing new treatments for infertility and related conditions. If successful, this research could lead to innovative therapies that improve reproductive health in older women.
Why it matters
Potential benefit: If successful, this research could provide new treatment options for women experiencing infertility due to aging.
How similar studies have gone: While the approach of using gene therapy for ovarian aging is innovative, similar studies in other areas of aging have shown promising results, suggesting potential for success.
Where this research is happening
-
Beth Israel Deaconess Medical Center
Boston, United States Active
Researchers
- Principal investigator: Neuhausser, Werner — Beth Israel Deaconess Medical Center
- Study coordinator: Neuhausser, Werner
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.