Reversing aging in human cells through gene reprogramming
Cellular and Tissue Rejuvenation through Transcriptional Reprogramming
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · NIH-11079586
This study is exploring ways to help aging cells feel young again by tweaking certain genes, with the hope of finding new and safer treatments for age-related health issues that could benefit people like you.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN FRANCISCO (nih funded) |
| Locations | 1 site (SAN FRANCISCO, UNITED STATES) |
| Trial ID | NIH-11079586 on ClinicalTrials.gov |
What this research studies
This research investigates how to rejuvenate aging human cells by manipulating specific genes involved in the aging process. The team uses a high-throughput screening method to identify transcription factors that can reverse the aging state of cells, effectively turning back the biological clock. By testing these factors in a controlled laboratory setting, they aim to discover safer and more effective alternatives to existing rejuvenation methods. The ultimate goal is to translate these findings into potential therapies for age-related conditions in humans.
Who could benefit from this research
Good fit: Ideal candidates for this research would be individuals experiencing age-related diseases or conditions, particularly those related to cellular aging.
Not a fit: Patients with acute or non-age-related conditions may not receive benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that restore youthful function to aging cells, potentially improving health and longevity.
How similar studies have performed: Previous studies have shown promising results in rejuvenating cells through transcriptional reprogramming, indicating that this approach has potential for success.
Where this research is happening
SAN FRANCISCO, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN FRANCISCO — SAN FRANCISCO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LI, HAO — UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- Study coordinator: LI, HAO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: age associated disease, age associated disorder, age dependent disease, age dependent disorder, age related human disease